The aryl hydrocarbon receptor and retinoid receptors cross-talk at the CYP1A1 promoter in vitro.

ABSTRACT: The epithelium of the small intestine plays an important role in detoxification processes due to the presence of various xenobiotic-metabolizing enzymes from phase I and II, as well as transport proteins of the ATP-binding cassette superfamily. Exposure to xenobiotics induces the expression of these proteins in the small intestine, with multiple signaling pathways stimulated by exogenous compounds converging at individual gene promoters by mechanisms which have not been fully understood yet. In this context the promoter region of the CYP1A1 gene, encoding the phase I monooxygenase cytochrome P450 1A1, was analyzed by chromatin immunoprecipitation with regard to binding of xeno-sensing receptors following stimulation of Caco-2 cells with agonists of the aryl hydrocarbon receptor (AHR

SUBMITTER: Hessel-Pras S 

PROVIDER: S-EPMC5938535 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature