In vitro gentamicin exposure alters caveolae protein profile in cochlear spiral ligament pericytes.

ABSTRACT:

Background

The aminoglycoside antibiotic gentamicin is an ototoxic drug and has been used experimentally to investigate cochlear damage induced by noise.We have investigated the changes in the protein profile associated with caveolae in gentamicin treated and untreated spiral ligament (SL) pericytes, specialized cells in the blood labyrinth barrier of the inner ear microvasculature. Pericytes from various microvascular beds express caveolae, protein and cholesterol rich microdomains, which can undergo endocytosis and transcytosis to transport small molecules in and out the cells. A different protein profile in transport-specialized caveolae may induce pathological changes affecting the integrity of the blood labyrinth barrier and ultimately contributing to hearing loss.

Method</

SUBMITTER: Ghelfi E 

PROVIDER: S-EPMC5938607 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature