Up-Down Reader: An Open Source Program for Efficiently Processing 50% von Frey Thresholds.

ABSTRACT: Most pathological pain conditions in patients and rodent pain models result in marked alterations in mechanosensation and the gold standard way to measure this is by use of von Frey fibers. These graded monofilaments are used to gauge the level of stimulus-evoked sensitivity present in the affected dermal region. One of the most popular methods used to determine von Frey thresholds is the up-down testing paradigm introduced by Dixon for patients in 1980 and by Chapman and colleagues for rodents in 1994. Although the up-down method is very accurate, leading to its widespread use, defining the 50% threshold from primary data is complex and requires a relatively time-consuming analysis step. We developed a computer program, the Up-Down Reader (UDReader), that can locate and recognize handwrit

SUBMITTER: Gonzalez-Cano R 

PROVIDER: S-EPMC5938897 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature