Septic predictor index: A novel platform to identify thermally injured patients susceptible to sepsis.

ABSTRACT:

Background

During the past decades' sepsis has become the major cause of death in severely burned patients. Despite the importance of burn sepsis, its diagnosis, let alone its prediction, is difficult if not impossible. Recently, we have demonstrated burn patients have increased NLRP3 inflammasome activation in white adipose tissue. We aimed to delineate a unique immune profile that can be used to identify septic outcomes in severely burned patients.

Methods

Adult burn patients (n = 37) admitted to our burn center between June 2013-2015 were enrolled in this study. White adipose tissue from the site of injury and plasma were collected from severely burned patients (>20% total body surface area) within 96 hours after thermal injury, indiscriminate of sex or age.

Results

SUBMITTER: Chen P 

PROVIDER: S-EPMC5939595 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature