Highly luminescent, biocompatible ytterbium(iii) complexes as near-infrared fluorophores for living cell imaging.

ABSTRACT: Herein, we report the design and synthesis of biocompatible Yb³⁺ complexes for near-infrared (NIR) living cell imaging. Upon excitation at either the visible (Soret band) or red region (Q band), these β-fluorinated Yb³⁺ complexes display high NIR luminescence (quantum yields up to 23% and 13% in dimethyl sulfoxide and water, respectively) and have higher stabilities and prolonged decay lifetimes (up to 249 μs) compared to the β-non-fluorinated counterparts. This renders the β-fluorinated Yb³⁺ complexes as a new class of biological optical probes in both steady-state imaging and time-resolved fluorescence lifetime imaging (FLIM). NIR confocal fluorescence images showed strong and specific intracellular Yb³⁺ luminescence signals when the biocompati

SUBMITTER: Ning Y 

PROVIDER: S-EPMC5939605 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature