Macrophage-mediated delivery of light activated nitric oxide prodrugs with spatial, temporal and concentration control.

ABSTRACT: Nitric oxide (NO) holds great promise as a treatment for cancer hypoxia, if its concentration and localization can be precisely controlled. Here, we report a "Trojan Horse" strategy to provide the necessary spatial, temporal, and dosage control of such drug-delivery therapies at targeted tissues. Described is a unique package consisting of (1) a manganese-nitrosyl complex, which is a photoactivated NO-releasing moiety (photoNORM), plus Nd³⁺-doped upconverting nanoparticles (Nd-UCNPs) incorporated into (2) biodegradable polymer microparticles that are taken up by (3) bone-marrow derived murine macrophages. Both the photoNORM [Mn(NO)dpaq^NO₂ ]BPh₄(dpaq^NO₂ = 2-[N,N-bis(pyridin-2-yl-methyl)]-amino-N'-5-nitro-

SUBMITTER: Evans MA 

PROVIDER: S-EPMC5939611 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature