Association of Common Genetic Variants With Contralateral Breast Cancer Risk in the WECARE Study.

ABSTRACT:

Background

Women with unilateral breast cancer (UBC) are at risk of developing a subsequent contralateral breast cancer (CBC). Common variants are associated with breast cancer risk. Whether these influence CBC risk is unknown.

Methods

Participants were breast cancer cases from the population-based Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study. Sixty-seven established breast cancer risk loci were genotyped directly or by imputation in 1459 case subjects with CBC and 2126 UBC control subjects. An unweighted polygenic risk score (PRS) was created by summing the number of risk alleles for each directly genotyped single nucleotide polymorphism (SNP), or for imputed loci, the imputed dosage. A weighted PRS was calculated similarly, but where each SNP's co

SUBMITTER: Robson ME 

PROVIDER: S-EPMC5939625 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature