Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.

ABSTRACT: Quantitative proteomics of postmortem human brain can identify dysfunctional proteins that contribute to neurodegenerative disorders like Alzheimer disease (AD) and frontotemporal dementia. Similar studies in chronic traumatic encephalopathy (CTE) are limited, therefore we hypothesized that proteomic sequencing of CTE frontal cortex brain homogenates from varying CTE pathologic stages may provide important new insights into this disorder. Quantitative proteomics of control, CTE and AD brains was performed to characterize differentially expressed proteins, and we identified over 4000 proteins in CTE brains, including significant enrichment of the microtubule associated protein tau. We also found enrichment and pathologic aggregation of RNA processing factors as seen previously in AD, suppor

SUBMITTER: Cherry JD 

PROVIDER: S-EPMC5939631 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature