Elevated Bladder Cancer in Northern New England: The Role of Drinking Water and Arsenic.

ABSTRACT: Bladder cancer mortality rates have been elevated in northern New England for at least five decades. Incidence rates in Maine, New Hampshire, and Vermont are about 20% higher than the United States overall. We explored reasons for this excess, focusing on arsenic in drinking water from private wells, which are particularly prevalent in the region. In a population-based case-control study in these three states, 1213 bladder cancer case patients and 1418 control subjects provided information on suspected risk factors. Log transformed arsenic concentrations were estimated by linear regression based on measurements in water samples from current and past homes. All statistical tests were two-sided. Bladder cancer risk increased with increasing water intake (Ptrend = .003). This trend was statis

SUBMITTER: Baris D 

PROVIDER: S-EPMC5939854 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature