Confidence assignment for mass spectrometry based peptide identifications via the extreme value distribution.

ABSTRACT:

Motivation

There is a growing trend for biomedical researchers to extract evidence and draw conclusions from mass spectrometry based proteomics experiments, the cornerstone of which is peptide identification. Inaccurate assignments of peptide identification confidence thus may have far-reaching and adverse consequences. Although some peptide identification methods report accurate statistics, they have been limited to certain types of scoring function. The extreme value statistics based method, while more general in the scoring functions it allows, demands accurate parameter estimates and requires, at least in its original design, excessive computational resources. Improving the parameter estimate accuracy and reducing the computational cost for this method has two advantages: it pr

SUBMITTER: Alves G 

PROVIDER: S-EPMC5939896 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature