The genetic association between iNOS and eNOS polymorphisms and gastric cancer risk: a meta-analysis.

ABSTRACT:

Objective

There are a number of susceptible factors for an increased risk of gastric cancer. Nitric oxide (NO) is considered to be associated with the development of a range of cancers. In particular, inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) are known to play a central role in the production of NO. Published studies relating to the association between eNOS rs1799983, rs2070744, and iNOS rs2297518 polymorphisms and the risk of gastric cancer risk are conflicting and inconclusive and require further analysis.

Materials and methods

This study involved a meta-analysis of case-control studies relating to eNOS rs1799983, rs2070744, and iNOS rs2297518 polymorphisms published prior to January 2018. Literature sea

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC5939909 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature