Neurocognitive dysfunction in HIV-infected youth: investigating the relationship with immune activation.

ABSTRACT:

Background

HIV-infected individuals are at increased risk of neurocognitive impairment compared to the general population. Studies suggest that, despite combination antiretroviral therapy (cART), HIV infection causes immune activation which results in neural damage; however, few data exist in HIV-infected youth.

Methods

HIV-infected youth 8-26-years-old on cART with virological suppression were prospectively enrolled along with healthy controls. Neurocognitive performance was assessed by age-appropriate Wechsler Intelligence Scales. Soluble and cellular markers of T-lymphocyte and monocyte activation were measured by ELISA and flow cytometry, respectively.

Results

45 HIV-infected subjects and 21 controls were enrolled. Markers of T-cell and monocyte activation were hi

SUBMITTER: Eckard AR 

PROVIDER: S-EPMC5940002 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature