Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease.

ABSTRACT:

Purpose

The ability of an endocrine disruptor exposure during gonadal sex determination to promote a transgenerational prostate disease phenotype was investigated in the current study.

Methods

Exposure of an F0 gestating female rat to the endocrine disruptor vinclozolin during F1 embryo gonadal sex determination promoted a transgenerational adult onset prostate disease phenotype. The prostate disease phenotype and physiological parameters were determined for males from F1 to F4 generations and the prostate transcriptome was assessed in the F3 generation.

Results

Although the prostate in prepubertal animals develops normally, abnormalities involving epithelial cell atrophy, glandular dysgenesis, prostatitis, and hyperplasia of the ventral prostate develop in older anim

SUBMITTER: Anway MD 

PROVIDER: S-EPMC5940006 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature