Stress resistance and lifespan enhanced by downregulation of antimicrobial peptide genes in the Imd pathway.

ABSTRACT: Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25°C. Gene expression analysis between the flies developed at 18°C and 25°C revealed that the Immune deficiency (Imd) pathway, including the downstream antimicrobial peptides (AMPs), is downregulated in the flies developed at 18°C. When hypomorphic imd mutant flies with reduced AMP expressions were developed at 25°C, they showed induced stress resistance with higher fat content in the body similar to the wild-type flies developed at 18°C. However, severe hypomorphic imd mutants could not enhance stress resistance due to t

SUBMITTER: Lin YR 

PROVIDER: S-EPMC5940113 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature