Haplotype-Based Genome-Wide Prediction Models Exploit Local Epistatic Interactions Among Markers.

ABSTRACT: Genome-wide prediction approaches represent versatile tools for the analysis and prediction of complex traits. Mostly they rely on marker-based information, but scenarios have been reported in which models capitalizing on closely-linked markers that were combined into haplotypes outperformed marker-based models. Detailed comparisons were undertaken to reveal under which circumstances haplotype-based genome-wide prediction models are superior to marker-based models. Specifically, it was of interest to analyze whether and how haplotype-based models may take local epistatic effects between markers into account. Assuming that populations consisted of fully homozygous individuals, a marker-based model in which local epistatic effects inside haplotype blocks were exploited (LEGBLUP) was linearly

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC5940160 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature