Network inference reveals novel connections in pathways regulating growth and defense in the yeast salt response.

ABSTRACT: Cells respond to stressful conditions by coordinating a complex, multi-faceted response that spans many levels of physiology. Much of the response is coordinated by changes in protein phosphorylation. Although the regulators of transcriptome changes during stress are well characterized in Saccharomyces cerevisiae, the upstream regulatory network controlling protein phosphorylation is less well dissected. Here, we developed a computational approach to infer the signaling network that regulates phosphorylation changes in response to salt stress. We developed an approach to link predicted regulators to groups of likely co-regulated phospho-peptides responding to stress, thereby creating new edges in a background protein interaction network. We then use integer linear programming (ILP) to inte

SUBMITTER: MacGilvray ME 

PROVIDER: S-EPMC5940180 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature