Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study.

ABSTRACT:

Background

Metformin constitutes first-line treatment of type 2 diabetes mellitus. It is presumed to have lactic acidosis as a dangerous, but rare, side effect.

Objectives

To estimate the incidence rate of lactic acidosis in patients with type 2 diabetes mellitus as well as to estimate the relative risk of lactic acidosis associated with metformin treatment.

Methods

This is a population-based combined cohort and case-control study among patients with type 2 diabetes mellitus who were acutely admitted with lactic acidosis at Odense University Hospital, Denmark; in the period from 1st June 2009 to 1st October 2013. The patients included as cases were all acutely hospitalized with lactic acidosis (pH <7.35 and lactate ≥2.0 mmol/l). For each case, we identified 24 age- an

SUBMITTER: Aharaz A 

PROVIDER: S-EPMC5940216 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature