The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement.

ABSTRACT: The brain transforms the need for water into the desire to drink, but how this transformation is performed remains unknown. Here we describe the motivational mechanism by which the forebrain thirst circuit drives drinking. We show that thirst-promoting subfornical organ neurons are negatively reinforcing and that this negative-valence signal is transmitted along projections to the organum vasculosum of the lamina terminalis (OVLT) and median preoptic nucleus (MnPO). We then identify molecularly defined cell types within the OVLT and MnPO that are activated by fluid imbalance and show that stimulation of these neurons is sufficient to drive drinking, cardiovascular responses, and negative reinforcement. Finally, we demonstrate that the thirst signal exits these regions through at least thre

SUBMITTER: Leib DE 

PROVIDER: S-EPMC5940335 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature