Pili Assembled by the Chaperone/Usher Pathway in Escherichia coli and Salmonella.

ABSTRACT: Gram-negative bacteria assemble a variety of surface structures, including the hair-like organelles known as pili or fimbriae. Pili typically function in adhesion and mediate interactions with various surfaces, with other bacteria, and with other types of cells such as host cells. The chaperone/usher (CU) pathway assembles a widespread class of adhesive and virulence-associated pili. Pilus biogenesis by the CU pathway requires a dedicated periplasmic chaperone and integral outer membrane protein termed the usher, which forms a multifunctional assembly and secretion platform. This review addresses the molecular and biochemical aspects of the CU pathway in detail, focusing on the type 1 and P pili expressed by uropathogenic Escherichia coli as model systems. We provide an overview of represe

SUBMITTER: Werneburg GT 

PROVIDER: S-EPMC5940347 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature