Prognostic value of the DNA integrity index in patients with malignant lung tumors.

ABSTRACT:

Introduction

Lung cancer survival remains poor in the western world due to late presentation in most cases, leading to difficulty of treatment in these advanced and metastatic patients. Therefore, the development of a robust biomarker for prognosis and to monitor treatment response and relapse would be of great benefit. The use of Alu repeats and DNA Integrity Index has been shown to hold both diagnostic and prognostic value, and as it is obtained from the plasma of patients, it can serve as a non-invasive tool for routine monitoring. This study evaluates the efficiency of this technique in malignant lung cancer patients.

Methods

Plasma samples were collected from 48 patients, consisting of 29 lung cancer patients and 19 non-cancer controls. Alu repeat ratio and confounders

SUBMITTER: Chudasama DY 

PROVIDER: S-EPMC5940399 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature