Long term deficiency of vitamin D in germ cell testicular cancer survivors.

ABSTRACT:

Background

Cisplatin-based chemotherapy significantly improved the survival of patients with germ cell testicular cancer. However, long term side effects of chemotherapy have non-negligible impact on the quality of life of these young patients, who have a long life expectancy after being successfully treated.

Materials and methods

25-OH vitamin D, testosterone, FSH and LH of patients with testicular cancer were retrospectively evaluated and for each patient clinical information were collected. The tissue of 52 patients with germ cell tumors was analyzed for VDR expression by immunohistochemistry. The serum 25-OH vitamin D and VDR expression were correlated to the patients 'clinical characteristics.

Results

25-OH vitamin D was analyzed in 82 patients. Insufficient (< 3

SUBMITTER: Nappi L 

PROVIDER: S-EPMC5940414 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature