Prevalence of Obstructive Sleep Apnea in Children With Down Syndrome: A Meta-Analysis.

ABSTRACT: STUDY OBJECTIVES:To estimate the prevalence of obstructive sleep apnea (OSA) in children with Down syndrome. METHODS:Two authors independently searched databases, namely PubMed, MEDLINE, EMBASE, and the Cochrane Review database. The keywords used were "Down syndrome," "Trisomy 21," "OSA," "sleep apnea syndromes," "polysomnography" and "polygraphy." The prevalence of OSA based on apnea-hypopnea index (AHI) greater than 1, 1.5, 2, 5, and 10 event/h was estimated using a random-effects model. Subgroup analyses were conducted for children in different countries, sample size, study year, and risk of bias. Finally, the prevalence of OSA was compared between two types of sleep studies (polysomnography versus polygraphy). RESULTS:A total of 18 studies (1,200 children) were included (mean age: 7.7

SUBMITTER: Lee CF 

PROVIDER: S-EPMC5940439 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature