Inflammatory Macrophage Expansion in Pulmonary Hypertension Depends upon Mobilization of Blood-Borne Monocytes.

ABSTRACT: Pulmonary inflammation, which is characterized by the presence of perivascular macrophages, has been proposed as a key pathogenic driver of pulmonary hypertension (PH), a vascular disease with increasing global significance. However, the mechanisms of expansion of lung macrophages and the role of blood-borne monocytes in PH are poorly understood. Using multicolor flow cytometric analysis of blood in mouse and rat models of PH and patients with PH, an increase in blood monocytes was observed. In parallel, lung tissue displayed increased chemokine transcript expression, including those responsible for monocyte recruitment, such as Ccl2 and Cx₃cl1, accompanied by an expansion of interstitial lung macrophages. These data indicate that blood monocytes are recruited to l

SUBMITTER: Florentin J 

PROVIDER: S-EPMC5940510 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature