Hippocampal Network Modularity Is Associated With Relational Memory Dysfunction in Schizophrenia.

ABSTRACT:

Background

Functional dysconnectivity has been proposed as a major pathophysiological mechanism for cognitive dysfunction in schizophrenia. The hippocampus is a focal point of dysconnectivity in schizophrenia, with decreased hippocampal functional connectivity contributing to the marked memory deficits observed in patients. Normal memory function relies on the interaction of complex corticohippocampal networks. However, only recent technological advances have enabled the large-scale exploration of functional networks with accuracy and precision.

Methods

We investigated the modularity of hippocampal resting-state functional networks in a sample of 45 patients with schizophrenia spectrum disorders and 38 healthy control subjects. Modularity was calculated for two distinct func

SUBMITTER: Avery SN 

PROVIDER: S-EPMC5940573 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature