Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure.

ABSTRACT: Linx is a member of the leucine-rich repeat and immunoglobulin family of membrane proteins which has critical roles in the development of the peripheral nervous system and forebrain connectivity. A previous study showed that Linx is expressed in projection neurons in the cortex and in cells that comprise the passage to the prethalamus that form the internal capsule, indicating the involvement of Linx in axon guidance and cell-cell communication. In this study, we found that Linx-deficient mice develop severe hydrocephalus and die perinatally by unknown mechanisms. Importantly, mice heterozygous for the linx gene exhibited defects in the development of the anterior commissure in addition to hydrocephalus, indicating haploinsufficiency of the linx gene in forebrain development. In N1E-115 ne

SUBMITTER: Abudureyimu S 

PROVIDER: S-EPMC5940738 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature