Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model.

ABSTRACT: High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure - intraocular pressure) may be as important as intraocular pressure alone. Thus, systemic hypertension would be protective against glaucoma. Epidemiological studies, however, are inconclusive. One theory of why hypertension may not protect against elevated intraocular pressure in spite of increasing ocular perfusion pressure is that with time, morphological changes to the vasculature and autoregulatory failure outweigh the benefits of improved perfusion pressure, ultimately leading to poor retinal and optic nerve head blood supply. In this study we sho

SUBMITTER: van Koeverden AK 

PROVIDER: S-EPMC5940769 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature