Evidence of CD4⁺ T cell-mediated immune pressure on the Hepatitis C virus genome.

ABSTRACT: Hepatitis C virus (HCV)-specific T cell responses are critical for immune control of infection. Viral adaptation to these responses, via mutations within regions of the virus targeted by CD8⁺ T cells, is associated with viral persistence. However, identifying viral adaptation to HCV-specific CD4⁺ T cell responses has been difficult although key to understanding anti-HCV immunity. In this context, HCV sequence and host genotype from a single source HCV genotype 1B cohort (n = 63) were analyzed to identify viral changes associated with specific human leucocyte antigen (HLA) class II alleles, as these variable host molecules determine the set of viral peptides presented to CD4⁺ T cells. Eight sites across the HCV genome were associated with HLA class II allele

SUBMITTER: Lucas M 

PROVIDER: S-EPMC5940905 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature