Comparative Population Genomics Analysis of the Mammalian Fungal Pathogen <i>Pneumocystis</i>.

ABSTRACT: Pneumocystis species are opportunistic mammalian pathogens that cause severe pneumonia in immunocompromised individuals. These fungi are highly host specific and uncultivable in vitro Human Pneumocystis infections present major challenges because of a limited therapeutic arsenal and the rise of drug resistance. To investigate the diversity and demographic history of natural populations of Pneumocystis infecting humans, rats, and mice, we performed whole-genome and large-scale multilocus sequencing of infected tissues collected in various geographic locations. Here, we detected reduced levels of recombination and variations in historical demography, which shape the global population structures. We report estimates of evolutionary rates, levels of genetic diversit

SUBMITTER: Cisse OH 

PROVIDER: S-EPMC5941068 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature