Ensemble allosteric model: energetic frustration within the intrinsically disordered glucocorticoid receptor.

ABSTRACT: Allostery is an important regulatory phenomenon enabling precise control of biological function. Initial understanding of allostery was gained from seminal work on conformational changes exhibited by structured proteins. Within the last decade, protein allostery has also been demonstrated to occur within intrinsically disordered proteins. This emerging concept of disorder-mediated allostery can be usefully understood in the context of a thermodynamic ensemble. The advantage of this ensemble allosteric model is that it unifies the explanations of allostery occurring within both structured and disordered proteins. One central finding from this model is that energetic coupling, the transmission of a signal between separate regions (or domains) of a protein, is maximized when one or more domai

SUBMITTER: White JT 

PROVIDER: S-EPMC5941170 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature