Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation.

ABSTRACT:

Background

Sex differences in the incidence and prognosis of respiratory diseases have been reported. Studies have shown that women are at increased risk of adverse health outcomes from air pollution than men, but sex-specific immune gene expression patterns and regulatory networks have not been well studied in the lung. MicroRNAs (miRNAs) are environmentally sensitive posttranscriptional regulators of gene expression that may mediate the damaging effects of inhaled pollutants in the lung, by altering the expression of innate immunity molecules.

Methods

Male and female mice of the C57BL/6 background were exposed to 2 ppm of ozone or filtered air (control) for 3 h. Female mice were also exposed at different stages of the estrous cycle. Following exposure, lungs were harvested

SUBMITTER: Fuentes N 

PROVIDER: S-EPMC5941588 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature