Exploring gene expression biomarker candidates for neurobehavioral impairment from total sleep deprivation.

ABSTRACT:

Background

Although sleep deprivation is associated with neurobehavioral impairment that may underlie significant risks to performance and safety, there is no reliable biomarker test to detect dangerous levels of impairment from sleep loss in humans. This study employs microarrays and bioinformatics analyses to explore candidate gene expression biomarkers associated with total sleep deprivation (TSD), and more specifically, the phenotype of neurobehavioral impairment from TSD. Healthy adult volunteers were recruited to a sleep laboratory for seven consecutive days (six nights). After two Baseline nights of 10 h time in bed, 11 subjects underwent an Experimental phase of 62 h of continuous wakefulness, followed by two Recovery nights of 10 h time in bed. Another six subjects underwe

SUBMITTER: Uyhelji HA 

PROVIDER: S-EPMC5941663 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature