Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin.

ABSTRACT:

Aim

This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment.

Methods

Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923).

Results

SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment.

Conclusion

This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly du

SUBMITTER: Levran O 

PROVIDER: S-EPMC5941712 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature