The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis.

ABSTRACT:

Objective

The bone morphogenetic proteins (BMPs) play crucial roles in tooth development. However, several BMPs retain expression in the dentin of the fully patterned and differentiated tooth. We hypothesized that BMP signaling therefore plays a role in the function of the differentiated odontoblast, the job of which is to lay down and mineralize the dentin matrix.

Design

We generated mice deficient in Bmp2 and 4 using a dentin matrix protein 1 (Dmp1) promoter-driven cre recombinase that was expressed in differentiated odontoblasts.

Results

The first and second molars of these Bmp2 and Bmp4 double conditional knockout (DcKO) mice displayed reduced dentin and enlarged pulp chambers compared to cre-negative littermate controls. DcKO mouse dentin in first molars was char

SUBMITTER: Jani P 

PROVIDER: S-EPMC5941946 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature