Evolutionary conservation of Ebola virus proteins predicts important functions at residue level.

ABSTRACT:

Motivation

The recent outbreak of Ebola virus disease (EVD) resulted in a large number of human deaths. Due to this devastation, the Ebola virus has attracted renewed interest as model for virus evolution. Recent literature on Ebola virus (EBOV) has contributed substantially to our understanding of the underlying genetics and its scope with reference to the 2014 outbreak. But no study yet, has focused on the conservation patterns of EBOV proteins.

Results

We analyzed the evolution of functional regions of EBOV and highlight the function of conserved residues in protein activities. We apply an array of computational tools to dissect the functions of EBOV proteins in detail: (i) protein sequence conservation, (ii) protein-protein interactome analysis, (iii) structural modeling

SUBMITTER: Arslan A 

PROVIDER: S-EPMC5942362 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature