Glycated haemoglobin A_1c (HbA_1c) for detection of diabetes mellitus and impaired fasting glucose in Malawi: a diagnostic accuracy study.

ABSTRACT:

Objectives

To examine the accuracy of glycated haemoglobin A_1c (HbA_1c) in detecting type 2 diabetes and impaired fasting glucose among adults living in Malawi.

Design

A diagnostic validation study of HbA_1c. Fasting plasma glucose (FPG) ≥7.0 mmol/L was the reference standard for type 2 diabetes, and FPG between 6.1 and 6.9 mmol/L as impaired fasting glucose.

Participants

3645 adults (of whom 63% were women) recruited from two demographic surveillance study sites in urban and rural Malawi. This analysis excluded those who had a previous diagnosis of diabetes or had history of taking diabetes medication.

Results

HbA_1c demonstrated excellent validity to detect FPG-defined diabetes, with an area under the receiver operatin

SUBMITTER: Rathod SD 

PROVIDER: S-EPMC5942411 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature