Associating Symptom Phenotype and Genotype in Preeclampsia.

ABSTRACT: Preeclampsia is a complex genetic disorder with an incompletely understood pathogenesis. Its phenotype may be better elucidated by integrating symptoms. This study aimed to identify symptoms by gestational age and associations with novel preeclampsia candidate genes. Women with a history of preeclampsia recruited from The Preeclampsia Registry completed clinical/demographic, symptom surveys and provided medical records. DNA extracted from saliva was processed with multiplexed assays for eight single-nucleotide polymorphisms (SNPs) selected to tag candidate genes and/or located in symptom susceptibility regions. Groups with versus without symptoms were compared using χ². Associations between SNPs and symptoms were analyzed as genotype categories and presence/absence of the varian

SUBMITTER: Founds SA 

PROVIDER: S-EPMC5942529 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature