NS1 codon usage adaptation to humans in pandemic Zika virus.

ABSTRACT:

Background

Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks with millions of human infections. The recent human infections of ZIKV were also associated with severe complications, such as an increase in cases of Guillain-Barre syndrome and the emergence of congenital Zika syndrome.

Objectives

To better understand the recent and rapid expansion of ZIKV, as well as the presentation of novel complications, we compared the genetic differences between the African sylvatic lineage and the Asian epidemic lineage that caused the

SUBMITTER: Freire CCM 

PROVIDER: S-EPMC5942634 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature