Association between urinary free light chains and progression to end stage renal disease in chronic kidney disease.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) are at an increased risk of developing end-stage renal disease (ESRD). We assessed for the first time whether urinary free light chains (FLC) are independently associated with risk of ESRD in patients with CKD, and whether they offer incremental value in risk stratification.

Materials and methods

We measured urinary FLCs in 556 patients with CKD from a prospective cohort study. The association between urinary kappa/creatinine (KCR) and lambda/creatinine (LCR) ratios and development of ESRD was assessed by competing-risks regression (to account for the competing risk of death). The change in C-statistic and integrated discrimination improvement were used to assess the incremental value of adding KCR or LCR to the Kidney Fa

SUBMITTER: Fenton A 

PROVIDER: S-EPMC5942781 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature