Prior subclinical histoplasmosis revealed in Nigeria using histoplasmin skin testing.

ABSTRACT:

Objectives

Disseminated histoplasmosis is an AIDS-defining illness. Histoplasmosis is commonly misdiagnosed as tuberculosis. Nigeria has the second highest number of people living with HIV/AIDS in Africa. The present study was carried out to investigate the prevalence of skin sensitivity amongst Nigerians to histoplasmin.

Design

A cross-sectional study was conducted in six centres across five geopolitical zones of Nigeria.

Methods

We recruited both healthy non-HIV and HIV-positive adults with CD4 count ≥ 350 cells/mm3 regardless of their ART status from March to May 2017. Skin tests were performed intradermally; induration ≥5 mm were considered to be histoplasmin positive.

Results

750 participants were recruited from Lagos (n = 52), Yola (n = 156), Ilorin (n =

SUBMITTER: Oladele RO 

PROVIDER: S-EPMC5942784 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature