Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway.

ABSTRACT:

Background

A major feature of acute lung injury (ALI) is excessive inflammation in the lung. Vitexin is an active component from medicinal plants which has antioxidant and anti-inflammatory activities. Oxidative stress and inflammation play important roles in the pathophysiological processes in ALI. In the current study, we investigate the effect and potential mechanisms of Vitexin on lipopolysaccharide (LPS)-induced ALI.

Methods

ALI was induced by LPS intratracheal instillation in C57BL/6 wild-type mice and Nrf2 gene knocked down (Nrf2-/-) mice. One hour before LPS challenge, Vitexin or vehicle intraperitoneal injection was performed. Bronchoalveolar lavage fluid and lung tissues were examined for lung inflammation and injury at 24 h after LPS challenge.

Results

Our

SUBMITTER: Lu Y 

PROVIDER: S-EPMC5942793 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature