Canine leishmaniasis: Genome-wide analysis and antibody response to Lutzomyia longipalpis saliva.

ABSTRACT: The anti-inflammatory properties of sand fly saliva favor the establishment of the Leishmania infantum infection. In contrast, an antibody response against Lutzomyia longipalpis saliva is often associated with a protective cell-mediated response against canine visceral leishmaniasis. Genetic studies may demonstrate to what extent the ability to secrete anti-saliva antibodies depends on genetic or environmental factors. However, the genetic basis of canine antibody response against sand fly saliva has not been assessed. The aim of this study was to identify chromosomal regions associated with the anti-Lu. longipalpis salivary IgG response in 189 dogs resident in endemic areas in order to provide information for prophylactic strategies. Dogs were classified into five groups based on serologi

SUBMITTER: Batista LFS 

PROVIDER: S-EPMC5942812 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature