RosettaAntibodyDesign (RAbD): A general framework for computational antibody design.

ABSTRACT: A structural-bioinformatics-based computational methodology and framework have been developed for the design of antibodies to targets of interest. RosettaAntibodyDesign (RAbD) samples the diverse sequence, structure, and binding space of an antibody to an antigen in highly customizable protocols for the design of antibodies in a broad range of applications. The program samples antibody sequences and structures by grafting structures from a widely accepted set of the canonical clusters of CDRs (North et al., J. Mol. Biol., 406:228-256, 2011). It then performs sequence design according to amino acid sequence profiles of each cluster, and samples CDR backbones using a flexible-backbone design protocol incorporating cluster-based CDR constraints. Starting from an existing experimental or compu

SUBMITTER: Adolf-Bryfogle J 

PROVIDER: S-EPMC5942852 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature