Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns.

ABSTRACT:

Objective

Lp(a) (lipoprotein(a)) concentrations are widely genetically determined by the LPA isoforms and show 5-fold interpopulation differences. Two- to 3-fold differences have been reported even within Europe. Finns represent a distinctive population isolate within Europe and have been repeatedly reported to present lower Lp(a) concentrations than Central Europeans. The significance of this finding was unclear for a long time because of the difficult comparability of Lp(a) assays. Recently, a large standardized study in >50 000 individuals from 7 European populations confirmed this observation but could not provide insights into the causes.

Approach and results

We investigated Lp(a) concentrations, LPA isoforms, and genotypes of established genetic variants

SUBMITTER: Erhart G 

PROVIDER: S-EPMC5943067 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature