Association of BET1L and TNRC6B with uterine leiomyoma risk and its relevant clinical features in Han Chinese population.

ABSTRACT: Previous studies have shown that uterine leiomyomas (UL) are benign tumours with contributions from environmental and genetic factors. We aimed to replicate two initial significant genetic factors, TNRC6B and BET1L, in a Han Chinese population. A total of 2,055 study subjects were recruited, and 55 SNPs mapped to TNRC6B and BET1L were selected and genotyped in samples from these subjects. Genetic associations were analysed at both the single marker and haplotype levels. Associations between targeted SNPs and relevant clinical features of UL were analysed in case only samples. Functional consequences of significant SNPs were analysed by bioinformatics tools. Two SNPs, rs2280543 from BET1L (χ² = 18.3, OR = 0.64, P = 1.87 × 10^-5) and rs12484776 from TNRC6B (χ²

SUBMITTER: Liu B 

PROVIDER: S-EPMC5943279 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature