Amino acid compositions contribute to the proteins' evolution under the influence of their abundances and genomic GC content.

ABSTRACT: Inconsistent results on the association between evolutionary rates and amino acid composition of proteins have been reported in eukaryotes. However, there are few studies of how amino acid composition can influence evolutionary rates in bacteria. Thus, we constructed linear regression models between composition frequencies of amino acids and evolutionary rates for bacteria. Compositions of all amino acids can on average explain 21.5% of the variation in evolutionary rates among 273 investigated bacterial organisms. In five model organisms, amino acid composition contributes more to variation in evolutionary rates than protein abundance, and frequency of optimal codons. The contribution of individual amino acid composition to evolutionary rate varies among organisms. The closer the GC-conte

SUBMITTER: Du MZ 

PROVIDER: S-EPMC5943316 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature