Expressional analysis of disease-relevant signalling-pathways in primary tumours and metastasis of head and neck cancers.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) often metastasize to lymph nodes resulting in poor prognosis for patients. Unfortunately, the underlying molecular mechanisms contributing to tumour aggressiveness, recurrences, and metastasis are still not fully understood. However, such knowledge is key to identify biomarkers and drug targets to improve prognosis and treatments. Consequently, we performed genome-wide expression profiling of 15 primary HNSSCs compared to corresponding lymph node metastases and non-malignant tissue of the same patient. Differentially expressed genes were bioinformatically exploited applying stringent filter criteria, allowing the discrimination between normal mucosa, primary tumours, and metastases. Signalling networks involved in invasion contain remodelling o

SUBMITTER: Goesswein D 

PROVIDER: S-EPMC5943339 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature