Transcriptomic integration of D₄R and MOR signaling in the rat caudate putamen.

ABSTRACT: Morphine binding to opioid receptors, mainly to μ opioid receptor (MOR), induces alterations in intracellular pathways essential to the initial development of addiction. The activation of the dopamine D₄ receptor (D₄R), which is expressed in the caudate putamen (CPu), mainly counteracts morphine-induced alterations in several molecular networks. These involve transcription factors, adaptive changes of MOR signaling, activation of the nigrostriatal dopamine pathway and behavioural effects, underlining functional D₄R/MOR interactions. To shed light on the molecular mechanisms implicated, we evaluated the transcriptome alterations following acute administration of morphine and/or PD168,077 (D₄R agonist) using whole-genome microarrays and a linear re

SUBMITTER: Valderrama-Carvajal A 

PROVIDER: S-EPMC5943359 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature