Identification of transcriptome signature for predicting clinical response to bevacizumab in recurrent glioblastoma.

ABSTRACT: Glioblastomas are among the most fatal brain tumors. Although no effective treatment option is available for recurrent glioblastomas (GBMs), a subset of patients evidently derived clinical benefit from bevacizumab, a monoclonal antibody against vascular endothelial growth factor. We retrospectively reviewed patients with recurrent GBM who received bevacizumab to identify biomarkers for predicting clinical response to bevacizumab. Following defined criteria, the patients were categorized into two clinical response groups, and their genetic and transcriptomic results were compared. Angiogenesis-related gene sets were upregulated in both responders and nonresponders, whereas genes for each corresponding angiogenesis pathway were distinct from one another. Two gene sets were made, namely, the

SUBMITTER: Choi SW 

PROVIDER: S-EPMC5943425 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature