Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.

ABSTRACT: Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (r_g  = 0.23, P = 9.3 × 10^-3 ), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10^-3 ) and concordance in effect direction (P = 2.0 × 10^-3 ) between the two

SUBMITTER: Painter JN 

PROVIDER: S-EPMC5943470 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature