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Antibiotic-mediated bacteriome depletion in Apc^Min/+ mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression.

ABSTRACT: Recent epidemiological evidence suggests that exposure to antibiotics in early-to-middle adulthood is associated with an increased risk of colorectal adenoma. However, mechanistic studies in established preclinical cancer to examine these claims are extremely limited. Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the Apc^Min/+ mouse, an established genetic model for familial adenomatous polyposis. Clinical pathologies related to tumor development as well as intestinal and colon tissue histopathology were studied at ages 8, 12, and 16 weeks of age, which correspond to the approximate ages of development of neoplasia, gut inflammation with polyposis, a

SUBMITTER: Kaur K

PROVIDER: S-EPMC5943478 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Antibiotic-mediated bacteriome depletion in Apc^Min/+ mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Antibiotic-mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Antibiotic-mediated bacteriome depletion in Apc^Min/+ mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression.